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Medical University of Vienna

Karolinska Institutet

Aims of research

We are known for running projects that tackle different aspects of organismal biology. We look at a range of live systems from a mechanistic point of view, trying to reverse engineer different aspects of multicellular life. Tracing the incremental advancements in development of multicellular organisms from a single cell perspective allows better understanding of the complexity of the entire organism or organ system in a final phase. That is why our main strength is developmental biology. The knowledge gained from developmental biology research is widely applied in regenerative medicine. Thus, we hope to improve human health via discovering new fundamental ideas about how development, stem cells, and regeneration work.

Our laboratory advances a broad spectrum of projects related to developmental biology, stem cells, EvoDevo and regenerative medicine. The methodology includes classical developmental biology approaches blended with single cell transcriptomics, 2D sequencing and 3D-reconstructions of tissues and organs based on optical or X-ray methods (micro-CT, synchrotron).

The neural crest stem cells is our primary model system, where we address general principles of cell fate choice, transcriptional and epigenetic control of a lineage progression, morphogenesis, and tissue shaping.

Lab competences

embryo

Developmental studies

Lineage tracing
Cell type ablation
Cell selection via FACS

confocal

Advanced imaging

RNAscope
MERFISH (coming soon)
Slide-seq (coming soon)

scRNAseq

Advanced bioinformatics

scRNAseq and scATACseq
Trajectory analysis and viral barcoding
Non-model organism exploration

Recent Publications

Schwann cell precursors represent a neural crest-like state with biased multipotency

The EMBO Journal, (2022)

Serotonin limits generation of chromaffin cells during adrenal organ development

Nature Communications, (2022)

Surface flow for colonial integration in reef-building corals

Current Biology, (2022)

The transcriptional portraits of the neural crest at the individual cell level

Seminars in Cell & Developmental Biology, (2022)

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

Nature Genetics, (2021)

Contact

  • 4 Spitalgasse, Wien, 1090, Austria