Research Group Leader (PI)
Currently my work is concentrated on different aspects of stem cell biology. I am generally interested in understanding the principles of animal design. To be more detailed, I try to focus on cellular aspects of development and evolution, elaboration of novelties in cellular lineages, issues of biological individuality and competition of cells inside of the multicellular organisms.
Artem is experienced in computational biology and epigenetics. He is interested in the drivers of cell fate decisions. Artem explores single cell gene expression and ATAC-seq data to infer the mechanisms of gene regulation. He also analyzes cell differentiation and spatial patterning during facial development.
Research Assistant Bioinformatics
Tatiana is an expert in bioinformatics. Her expertise in single cell transcriptomics analysis is crucial for our laboratory. Her work is dedicated to the discovery of major principles of tissue heterogeneity, stem cell regulation, evolution of novel cell types and transitions between gene regulatory networks.
Alek studies how functional architecture is generated during development, and is now investigating how the vertebrate head integrates morphogenesis of distinct lineages such as the nervous and skeletal organs. He is curious how groups of cells process information of various modalities across length and time scales to achieve what resembles spatiotemporal awareness, memory, and purposeful behavior. He is also concerned with a strong connection between basic science and the humanities.
My PhD aims to to expand our views on the evolution of neural crest properties. More precisely by unravelling the cell fate decisions of neural crests cells during mouse development and by exploring the heterogeneity of glial cells during development and adulthood in mouse. This work is mainly based on the usage of bioinformatic tools such as single-cell transcriptomics data analysis, clustering, pseudotime ordering, combined with biological experiments for validation.
Polina has an expertise in analysis of lipids and lipid-like molecules using high resolution chromatograpy mass-spectrometry. She is excited to study in the role of lipids in the development of peripheral nervous system and the formation of myelin. Currently she is getting more experience in using mouse models, single cell transcriptomic data and immunohistochemistry in the project devoted to the development of neuroendocrine organs.
Maria Eleni primarily works on embryonic and adult peripheral glial heterogeneity with the help of single cell transcriptomics approach. Her projects are focused around multipotency of Schwann cell precursors and their differentiation trajectories.
Marketa attempts to explain cell dynamics and its regulation during the induction and shaping of cartilage in the head. She is looking into formation of the mammalian face and, on the other hand, she investigates how inherited features make us unique and different from each other.
Julian is working of heterogeneity and hierarchy of progenitor cell types in facial development with the help of single cell transcriptomics. He also looks into the neural crest development and fate choice issues.
Kazunori is an expert in muscle biology. He works on formation of the cartilage-tendon-muscle interface. Kazunori works a lot with zebrafish model system, he creates new transgenic strains and performs sophisticated experiments involving live imaging, genetic tracing and various ablations of cell types during early development.
Bara is an expert in gene expression analysis and she mainly works on multiplexing various gene expression validation techniques such as FISH and others.
Meng investigates shape development in biological systems, primarily of skeletal and dental elements in the vertebrate body. He is currently focusing on the process of joint formation in mouse, zebrafish and salamander.
Honored Associated Member
Kaj Fried has a long-standing experience from studies of the development and trigeminal innervation of teeth. Over the years Kaj investigated an array of various dental nerve-target interactions, with focus on developmental processes. Special emphasis has been given to the neural molecular factors at early stages of tooth organogenesis.
Assistant Professor (PI)
Viacheslav is our key collaborator and young group leader at the Department of Neuroscience. His team mainly works on parasympathetic nervous system development.
Prof. Jozef Kaiser (CEITEC, Brno, Czech Republic) is a world-leading expert in tomography and 3D-reconstructions. We collaborate on the projects related to facial development, shaping and cartilage growth.
Assistant Professor (PI)
Peter is a recognized expert in single cell transcriptomics, other newly emerging NGS methods, highly sophisticated bioinformatics. Peter is an acknowledged developer of new mathematical and programming tools for the gene expression analysis. Peter and his laboratory members at Harvard are our main partners on single cell transcriptomics part.
Natalia is a visiting PhD student. She came to us to learn how to work with transgenic mice and chick embryos. Natalia elegantly performs chick neural tube electroporation to study different aspects of ATPase subunit isoforms.
Visiting - PhD Student