Authors

Igor Adameyko, Francois Lallemend, Alessandro Furlan, Nikolay Zinin, Sergi Aranda, Satish Srinivas Kitambi, Albert Blanchart, Rebecca Favaro, Silvia Nicolis, Moritz Lübke, Thomas Müller, Carmen Birchmeier, Ueli Suter, Ismail Zaitoun, Yoshiko Takahashi, Patrik Ernfors

Journal

Development

Summary

The cellular origin and molecular mechanisms regulating pigmentation of head and neck are largely unknown. Melanocyte specification is controlled by the transcriptional activity of Mitf, but no general logic has emerged to explain how Mitf and progenitor transcriptional activities consolidate melanocyte and progenitor cell fates. We show that cranial melanocytes arise from at least two different cellular sources: initially from nerve- associated Schwann cell precursors (SCPs) and later from a cellular source that is ...

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